Relative Importance of NF- B p50 in Mycobacterial Infection
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چکیده
B p50 in κ Relative Importance of NF
منابع مشابه
Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.
Stimulation of the NF-kappaB pathway often causes p65-p50 and p50-p50 dimers to be simultaneously present in the cell nucleus. A natural polymorphism at nucleotide -863 in the human TNF promoter (encoding tumor necrosis factor [TNF]) region provides an opportunity to dissect the functional interaction of p65-p50 and p50-p50 at a single NF-kappaB binding site. We found that this site normally bi...
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Leishmania amazonensis activates the NF-kB transcriptional repressor homodimer (p50/p50) and promotes nitric oxide synthase (iNOS) downregulation. We investigated the role of PI3K/Akt in p50/p50 NF-kB activation and the effect on iNOS expression in L. amazonensis infection. The increased occupancy of p50/p50 on the iNOS promoter of infected macrophages was observed and we demonstrated that both...
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NF-kappaB signaling is critical to the survival and transformation of cells infected by the human gammaherpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus. Here we have examined how elimination of the NF-kappaB transcription factor p50 from mice affects the life cycle of murine gammaherpesvirus 68 (MHV68). Notably, mice lacking p50 in every cell type were unable to esta...
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Infection of specific types of 'high risk' HPVs such as HPV 16 and HPV 18 has been associated with the development of cervical cancer. Deregulation of specific NF-kappaB members has also been implicated with the development of many cancers including cervical cancer. We have studied the expression and DNA-binding activity of NF-kappaB during the development of cervical cancer involving cervical ...
متن کاملReduced phosphorylation of p50 is responsible for diminished NF-kappaB binding to the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells.
Reduced cell surface levels of major histocompatibility complex class I antigens enable adenovirus type 12 (Ad12)-transformed cells to escape immunosurveillance by cytotoxic T lymphocytes (CTL), contributing to their tumorigenic potential. In contrast, nontumorigenic Ad5-transformed cells harbor significant cell surface levels of class I antigens and are susceptible to CTL lysis. Ad12 E1A media...
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تاریخ انتشار 2001